Barcelona defender Jordi Alba and Atletico Madrid midfielder Koke are the notable absentees from Luis Enrique’s first Spain squad.
The new national team manager has picked his squad for the upcoming Nations League games against England and Croatia.
With Gerard Pique and Andres Iniesta retiring from international football, the absentees are particularly notable in signalling a new era.
Celta Vigo striker Iago Aspas is also absent from the squad, with Chelsea duo Alvaro Morata and Marcos Alonso returning along with goalkeeper Kepa Arrizabalaga.
Real Betis goalkeeper Pau Lopez, Real Sociedad defender Diego Llorente, Valencia full-back Jose Luis Gaya and Real Madrid midfielder Dani Ceballos are surprise inclusions.
Milan forward Suso and new Atletico Madrid midfielder Rodri are also included in the squad, alongside Athletic Club Bilbao’s Inigo Martinez.
Spain squad
Goalkeepers: De Gea, Kepa, Pau Lopez
Defenders: Carvajal, Azpilicueta, Albiol, Nacho, Ramos, Llorente, Inigo Martinez, Alonso, Gaya
Midfielders: Busquets, Sergi Roberto, Rodri, Saul, Thiago, Ceballos, Isco
Forwards: Asensio, Morata, Costa, Suso, Rodrigo
