Sevilla begin their Europa League defence in the last 32 against Molde, Villarreal face Napoli, Valencia tackle Rapid Vienna and Athletic Bilbao encounter Marseille.
Los Nervionenses, the competition’s most successful team with four triumphs, will look to make it three on the bounce when they take on the Norwegians, in the knockout stages for the first time in their history.
Valencia, meanwhile, join Sevilla in dropping into the Europa League from the Champions League and are drawn Rapid Vienna, who pipped Villarreal to top spot in their group.
The Yellow Submarines failure to topple the Austrians means a tough tie against last season’s semi-finalists Napoli awaits, while Athletic Bilbao make the short trip to Marseille in their first leg.
The first legs will be played on February 18, with the return fixtures scheduled a week later on the 25th.
Europa League last-32 draw in full:
Valencia v Rapid Vienna
Fiorentina v Tottenham Hotspur
Borussia Dortmund v Porto
Fenerbahce v Lokomotiv Moscow
Anderlecht v Olympiakos
Midtylland v Manchester United
Augsburg v Liverpool
Sparta Prague v Kuban Krasnodar
Galatasaray v Lazio
Sion v Braga
Shakhtar Donetsk v Schalke
Marseille v Athletic Bilbao
Sevilla v Molde
Sporting CP v Bayer Leverkusen
Villarreal v Napoli
Saint-Etienne v Basel